Product information "SARS-CoV-2 (2019-nCoV) Papain-Like Protease Protein , recombinant"
GenBank: QHD43415.1. Nsp3 is responsible for the cleavages located at the N-terminus of the replicase polyprotein. In addition, PL-PRO possesses a deubiquitinating/deISGylating activity and processes both "Lys-48"- and "Lys-63"-linked polyubiquitin chains from cellular substrates. Participates together with nsp4 in the assembly of virally-induced cytoplasmic double-membrane vesicles necessary for viral replication. Antagonizes innate immune induction of type I interferon by blocking the phosphorylation, dimerization and subsequent nuclear translocation of host IRF3. Prevents also host NF-kappa-B signaling. [The Uniprot Consortium]
| Keywords: | Non-structural protein 3, nsp3, PL2-PROPapain-like proteinase, PL-PRO, SARS coronavirus main proteinase |
| Supplier: | Elabscience |
| Supplier-Nr: | PKSR030472 |
Properties
| Conjugate: | No |
| Expressed in: | E.coli |
| Origin: | Sars-cov-2 |
| MW: | 34 kD |
| Purity: | > 90 % as determined by reducing SDS-PAGE. |
| Format: | Solution |
Handling & Safety
| Storage: | -20°C |
| Shipping: | -20°C (International: -20°C) |
Caution Our products are for laboratory research use only: Not for administration to humans!